Gene Regulation in the Third Dimension

by: Job Dekker

Science, Vol. 319, No. 5871. (28 March 2008), pp. 1793-1794.

View FullText article

DOI, HighWire, Pubmed, Hubmed

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

inesdesantiago, Khavkin's lab (group), ArtemPankin, emptyhb, operon, AbnerCYH, ealloza, biomcgary, sunhwan, GEB (group), dlobo, lambda, Haze

Find related articles with these CiteULike tags

biology, chromosome_distribution, expression, gene, gene_expression, genomics, geometries, microrna, no-tag, regulation, review, rna, spatial-organization, tba, transcriptional_regulation

Résumé

Analysis of the spatial organization of chromosomes reveals complex three-dimensional networks of chromosomal interactions. These interactions affect gene expression at multiple levels, including long-range control by distant enhancers and repressors, coordinated expression of genes, and modification of epigenetic states. Major challenges now include deciphering the mechanisms by which loci come together and understanding the functional consequences of these often transient associations. 10.1126/science.1152850

@article{citeulike:2604760, abstract = {Analysis of the spatial organization of chromosomes reveals complex three-dimensional networks of chromosomal interactions. These interactions affect gene expression at multiple levels, including long-range control by distant enhancers and repressors, coordinated expression of genes, and modification of epigenetic states. Major challenges now include deciphering the mechanisms by which loci come together and understanding the functional consequences of these often transient associations. 10.1126/science.1152850}, author = {Dekker, Job }, citeulike-article-id = {2604760}, doi = {10.1126/science.1152850}, journal = {Science}, keywords = {tba}, month = {March}, number = {5871}, pages = {1793--1794}, posted-at = {2008-07-16 10:42:26}, priority = {2}, title = {Gene Regulation in the Third Dimension}, url = {http://dx.doi.org/10.1126/science.1152850}, volume = {319}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2604760 L3 - citeulike-article-id:2604760 TI - Gene Regulation in the Third Dimension JF - Science VL - 319 IS - 5871 SP - 1793 EP - 1794 N2 - Analysis of the spatial organization of chromosomes reveals complex three-dimensional networks of chromosomal interactions. These interactions affect gene expression at multiple levels, including long-range control by distant enhancers and repressors, coordinated expression of genes, and modification of epigenetic states. Major challenges now include deciphering the mechanisms by which loci come together and understanding the functional consequences of these often transient associations. 10.1126/science.1152850 KW - tba AU - Dekker, Job PY - 2008/03/28/ UR - http://dx.doi.org/10.1126/science.1152850 ER -

RIS BibTeX