Vimentin affects the mobility and invasiveness of prostate cancer cells.

@article{citeulike:2791088, abstract = {A significant proportion of prostate cancer patients treated with curative intent go on to develop advanced disease. At a fundamental biological level, very little is known about what makes the disease aggressive and metastatic. Observational pathology reports and experimental data suggest that epithelial-mesenchymal transition is involved in prostate cancer invasiveness. Here, we investigated vimentin expression of prostate cancer cells, and explored the potential mechanism of vimentin promoting prostate cancer cells invasion. Vimentin expression was not detected in well differentiated tumors or in moderately differentiated tumors, but the majority of poorly differentiated cancers (5/11 with negative bone scan, 11/14 bone with positive scan) and bone metastases (8/8) had high vimentin expression in tumor cells. Downregulation of vimentin expression in PC-3 cells by transfection with antisense-vimentin led to a significant decrease in tumor cells motility and invasive activity. Furthermore, the expression of E-cadherin was inversely associated with expression of vimentin. Our results suggest that vimentin affects prostate cancer cells motility and invasiveness. Copyright (c) 2008 John Wiley \& Sons, Ltd.}, address = {Key Laboratory for Oral Biomedical Engineering, Ministry of Education, School \& Hospital of Stomatology, Wuhan University, Wuhan 430079, P.R. China.}, author = {Zhao, Yan and Yan, Quanmei and Long, Xing and Chen, Xinmin and Wang, Yining }, citeulike-article-id = {2791088}, doi = {10.1002/cbf.1478}, issn = {1099-0844}, journal = {Cell biochemistry and function}, keywords = {cancer, prostate}, month = {May}, posted-at = {2008-05-12 23:20:06}, priority = {2}, title = {Vimentin affects the mobility and invasiveness of prostate cancer cells.}, url = {http://dx.doi.org/10.1002/cbf.1478}, year = {2008} }

TY - JOUR ID - citeulike:2791088 L3 - citeulike-article-id:2791088 TI - Vimentin affects the mobility and invasiveness of prostate cancer cells. JF - Cell biochemistry and function AD - Key Laboratory for Oral Biomedical Engineering, Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, P.R. China. SN - 1099-0844 N2 - A significant proportion of prostate cancer patients treated with curative intent go on to develop advanced disease. At a fundamental biological level, very little is known about what makes the disease aggressive and metastatic. Observational pathology reports and experimental data suggest that epithelial-mesenchymal transition is involved in prostate cancer invasiveness. Here, we investigated vimentin expression of prostate cancer cells, and explored the potential mechanism of vimentin promoting prostate cancer cells invasion. Vimentin expression was not detected in well differentiated tumors or in moderately differentiated tumors, but the majority of poorly differentiated cancers (5/11 with negative bone scan, 11/14 bone with positive scan) and bone metastases (8/8) had high vimentin expression in tumor cells. Downregulation of vimentin expression in PC-3 cells by transfection with antisense-vimentin led to a significant decrease in tumor cells motility and invasive activity. Furthermore, the expression of E-cadherin was inversely associated with expression of vimentin. Our results suggest that vimentin affects prostate cancer cells motility and invasiveness. Copyright (c) 2008 John Wiley & Sons, Ltd. KW - cancer KW - prostate AU - Zhao, Yan AU - Yan, Quanmei AU - Long, Xing AU - Chen, Xinmin AU - Wang, Yining PY - 2008/05/08/ UR - http://dx.doi.org/10.1002/cbf.1478 ER -