Cancerous miRNAs and their regulation.

@article{citeulike:2800285, abstract = {Although they account for only a very minor fraction of the expressed genome, microRNAs (miRNAs) are pivotal regulators of development and cellular homeostasis through their control of diverse cellular processes including proliferation, differentiation, apoptosis, survival, motility, and morphogenesis. Accordingly, several miRNAs have been functionally classified as proto-oncogenes or tumor suppressors and are aberrantly expressed in different cancer types. Deregulation (e.g., overexpression or loss of expression) of these so-called "cancerous" miRNAs can figure prominently in tumor initiation and progression by elaborating an inappropriate cellular program promoting uncontrolled proliferation, favoring survival, inhibiting differentiation, and/or promoting invasive behavior. These features would certainly promote tumor dissemination and persistence by favoring metastasis and therapy resistance. Cancerous miRNAs therefore represent attractive molecules for exploitation as biomarkers and therapeutic targets. In this review, we highlight recently characterized cancerous miRNAs and the mechanisms through which they contribute to the pathogenesis of human cancers. We also discuss the signal transduction pathways that regulate the expression of these miRNAs with particular attention to several essential transcription factors such as Myc, p53, and the androgen receptor.}, address = {Department of Urology, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA.}, author = {Shi, Xu-Bao B. and Tepper, Clifford G. and White, Ralph W. }, citeulike-article-id = {2800285}, issn = {1551-4005}, journal = {Cell cycle (Georgetown, Tex.)}, keywords = {cancer, microrna}, month = {March}, number = {11}, posted-at = {2008-05-15 00:32:29}, priority = {2}, title = {Cancerous miRNAs and their regulation.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18469525}, volume = {7}, year = {2008} }

TY - JOUR ID - citeulike:2800285 L3 - citeulike-article-id:2800285 TI - Cancerous miRNAs and their regulation. JF - Cell cycle (Georgetown, Tex.) VL - 7 IS - 11 AD - Department of Urology, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA. SN - 1551-4005 N2 - Although they account for only a very minor fraction of the expressed genome, microRNAs (miRNAs) are pivotal regulators of development and cellular homeostasis through their control of diverse cellular processes including proliferation, differentiation, apoptosis, survival, motility, and morphogenesis. Accordingly, several miRNAs have been functionally classified as proto-oncogenes or tumor suppressors and are aberrantly expressed in different cancer types. Deregulation (e.g., overexpression or loss of expression) of these so-called "cancerous" miRNAs can figure prominently in tumor initiation and progression by elaborating an inappropriate cellular program promoting uncontrolled proliferation, favoring survival, inhibiting differentiation, and/or promoting invasive behavior. These features would certainly promote tumor dissemination and persistence by favoring metastasis and therapy resistance. Cancerous miRNAs therefore represent attractive molecules for exploitation as biomarkers and therapeutic targets. In this review, we highlight recently characterized cancerous miRNAs and the mechanisms through which they contribute to the pathogenesis of human cancers. We also discuss the signal transduction pathways that regulate the expression of these miRNAs with particular attention to several essential transcription factors such as Myc, p53, and the androgen receptor. KW - cancer KW - microrna AU - Shi, Xu-Bao AU - Tepper, Clifford AU - White, Ralph PY - 2008/03/19/ UR - http://view.ncbi.nlm.nih.gov/pubmed/18469525 ER -