A method for estimating the age-specific relative risk of HIV infection from AIDS incidence data

by: Niels G Becker, Ian C Marschner

Biometrika, Vol. 80, No. 1. (1 March 1993), pp. 165-178.

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Résumé

Using a multiplicative model, the age-specific relative risk of infection with the human immunodeficiency virus, HIV, and the time-dependent HIV infection rate can be estimated simultaneously from acquired immunodeficiency syndrome, AIDS, incidence data. Non-parametric estimates are arrived at by an EM-algorithm, with smoothing, applied to a back-projection model. The method gives estimates which lie on a smooth curve in accordance with strong prior expectations. The approach is illustrated with an application to Australian AIDS data. It is found that the HIV infection rate tends to be estimated more precisely when age is included as a covariate. 10.1093/biomet/80.1.165

@article{citeulike:1822769, abstract = {Using a multiplicative model, the age-specific relative risk of infection with the human immunodeficiency virus, HIV, and the time-dependent HIV infection rate can be estimated simultaneously from acquired immunodeficiency syndrome, AIDS, incidence data. Non-parametric estimates are arrived at by an EM-algorithm, with smoothing, applied to a back-projection model. The method gives estimates which lie on a smooth curve in accordance with strong prior expectations. The approach is illustrated with an application to Australian AIDS data. It is found that the HIV infection rate tends to be estimated more precisely when age is included as a covariate. 10.1093/biomet/80.1.165}, author = {Becker, Niels G. and Marschner, Ian C. }, citeulike-article-id = {1822769}, doi = {10.1093/biomet/80.1.165}, journal = {Biometrika}, keywords = {back-calculation, hiv, prion}, month = {March}, number = {1}, pages = {165--178}, posted-at = {2008-04-17 18:38:26}, priority = {2}, title = {A method for estimating the age-specific relative risk of HIV infection from AIDS incidence data}, url = {http://dx.doi.org/10.1093/biomet/80.1.165}, volume = {80}, year = {1993} }

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TY - JOUR ID - citeulike:1822769 L3 - citeulike-article-id:1822769 TI - A method for estimating the age-specific relative risk of HIV infection from AIDS incidence data JF - Biometrika VL - 80 IS - 1 SP - 165 EP - 178 N2 - Using a multiplicative model, the age-specific relative risk of infection with the human immunodeficiency virus, HIV, and the time-dependent HIV infection rate can be estimated simultaneously from acquired immunodeficiency syndrome, AIDS, incidence data. Non-parametric estimates are arrived at by an EM-algorithm, with smoothing, applied to a back-projection model. The method gives estimates which lie on a smooth curve in accordance with strong prior expectations. The approach is illustrated with an application to Australian AIDS data. It is found that the HIV infection rate tends to be estimated more precisely when age is included as a covariate. 10.1093/biomet/80.1.165 KW - back-calculation KW - hiv KW - prion AU - Becker, Niels AU - Marschner, Ian PY - 1993/03/01/ UR - http://dx.doi.org/10.1093/biomet/80.1.165 ER -

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