Evolution and multilevel optimization of the genetic code.

by: Tobias Bollenbach, Kalin Vetsigian, Roy Kishony

Genome Res (9 March 2007)

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Résumé

The discovery of the genetic code was one of the most important advances of modern biology. But there is more to a DNA code than protein sequence; DNA carries signals for splicing, localization, folding, and regulation that are often embedded within the protein-coding sequence. In this issue, Itzkovitz and Alon show that the specific 64-to-20 mapping found in the genetic code may have been optimized for permitting protein-coding regions to carry this extra information and suggest that this property may have evolved as a side benefit of selection to minimize the negative effects of frameshift errors.

@article{citeulike:1203700, abstract = {The discovery of the genetic code was one of the most important advances of modern biology. But there is more to a DNA code than protein sequence; DNA carries signals for splicing, localization, folding, and regulation that are often embedded within the protein-coding sequence. In this issue, Itzkovitz and Alon show that the specific 64-to-20 mapping found in the genetic code may have been optimized for permitting protein-coding regions to carry this extra information and suggest that this property may have evolved as a side benefit of selection to minimize the negative effects of frameshift errors.}, address = {Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA;}, author = {Bollenbach, Tobias and Vetsigian, Kalin and Kishony, Roy }, citeulike-article-id = {1203700}, doi = {http://dx.doi.org/10.1101/gr.6144007}, issn = {1088-9051}, journal = {Genome Res}, keywords = {evolution, genetic-code, genetics}, month = {March}, posted-at = {2007-09-17 12:43:22}, priority = {2}, title = {Evolution and multilevel optimization of the genetic code.}, url = {http://dx.doi.org/10.1101/gr.6144007}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1203700 L3 - citeulike-article-id:1203700 TI - Evolution and multilevel optimization of the genetic code. JF - Genome Res AD - Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA; SN - 1088-9051 N2 - The discovery of the genetic code was one of the most important advances of modern biology. But there is more to a DNA code than protein sequence; DNA carries signals for splicing, localization, folding, and regulation that are often embedded within the protein-coding sequence. In this issue, Itzkovitz and Alon show that the specific 64-to-20 mapping found in the genetic code may have been optimized for permitting protein-coding regions to carry this extra information and suggest that this property may have evolved as a side benefit of selection to minimize the negative effects of frameshift errors. KW - evolution KW - genetic-code KW - genetics AU - Bollenbach, Tobias AU - Vetsigian, Kalin AU - Kishony, Roy PY - 2007/03/09/ UR - http://dx.doi.org/10.1101/gr.6144007 ER -

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