Turing patterns inside cells.

@article{citeulike:2080629, abstract = {Concentration gradients inside cells are involved in key processes such as cell division and morphogenesis. Here we show that a model of the enzymatic step catalized by phosphofructokinase (PFK), a step which is responsible for the appearance of homogeneous oscillations in the glycolytic pathway, displays Turing patterns with an intrinsic length-scale that is smaller than a typical cell size. All the parameter values are fully consistent with classic experiments on glycolytic oscillations and equal diffusion coefficients are assumed for ATP and ADP. We identify the enzyme concentration and the glycolytic flux as the possible regulators of the pattern. To the best of our knowledge, this is the first closed example of Turing pattern formation in a model of a vital step of the cell metabolism, with a built-in mechanism for changing the diffusion length of the reactants, and with parameter values that are compatible with experiments. Turing patterns inside cells could provide a check-point that combines mechanical and biochemical information to trigger events during the cell division process.}, address = {Service de Chimie Physique and Center for Nonlinear Phenomena and Complex Systems, Universit\'{e} Libre de Bruxelles, Brussels, Belgium.}, author = {Strier, D. E. and Dawson Ponce, S. }, citeulike-article-id = {2080629}, doi = {10.1371/journal.pone.0001053}, issn = {1932-6203}, journal = {PLoS ONE}, keywords = {chaos, oscillations}, number = {10}, posted-at = {2007-12-09 01:40:51}, priority = {2}, title = {Turing patterns inside cells.}, url = {http://dx.doi.org/10.1371/journal.pone.0001053}, volume = {2}, year = {2007} }

TY - JOUR ID - citeulike:2080629 L3 - citeulike-article-id:2080629 TI - Turing patterns inside cells. JF - PLoS ONE VL - 2 IS - 10 AD - Service de Chimie Physique and Center for Nonlinear Phenomena and Complex Systems, Université Libre de Bruxelles, Brussels, Belgium. SN - 1932-6203 N2 - Concentration gradients inside cells are involved in key processes such as cell division and morphogenesis. Here we show that a model of the enzymatic step catalized by phosphofructokinase (PFK), a step which is responsible for the appearance of homogeneous oscillations in the glycolytic pathway, displays Turing patterns with an intrinsic length-scale that is smaller than a typical cell size. All the parameter values are fully consistent with classic experiments on glycolytic oscillations and equal diffusion coefficients are assumed for ATP and ADP. We identify the enzyme concentration and the glycolytic flux as the possible regulators of the pattern. To the best of our knowledge, this is the first closed example of Turing pattern formation in a model of a vital step of the cell metabolism, with a built-in mechanism for changing the diffusion length of the reactants, and with parameter values that are compatible with experiments. Turing patterns inside cells could provide a check-point that combines mechanical and biochemical information to trigger events during the cell division process. KW - chaos KW - oscillations AU - Strier, DE AU - Dawson Ponce, S PY - 2007/// UR - http://dx.doi.org/10.1371/journal.pone.0001053 ER -