Role of insulin-like signalling in Drosophila lifespan

by: Maria E Giannakou, Linda Partridge

Trends in Biochemical Sciences, Vol. 32, No. 4. (April 2007), pp. 180-188.

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Résumé

Regulation of lifespan by the insulin/insulin-like growth factor-like signalling (IIS) pathway has been conserved during evolution from the nematode worm to the mouse. In the insect Drosophila, regulation of lifespan by the IIS pathway was established by data showing that many mutations in single genes encoding IIS components result in an increase in lifespan. Recently, however, the focus has shifted from studying the effects of single gene mutations with ubiquitous effects to finding interventions that alter IIS in specific tissues and at specific stages in the life history of the fruitfly, in order to elucidate the signalling pathways at work and the mechanisms by which alterations in the IIS pathway can extend lifespan.

@article{citeulike:2121340, abstract = {Regulation of lifespan by the insulin/insulin-like growth factor-like signalling (IIS) pathway has been conserved during evolution from the nematode worm to the mouse. In the insect Drosophila, regulation of lifespan by the IIS pathway was established by data showing that many mutations in single genes encoding IIS components result in an increase in lifespan. Recently, however, the focus has shifted from studying the effects of single gene mutations with ubiquitous effects to finding interventions that alter IIS in specific tissues and at specific stages in the life history of the fruitfly, in order to elucidate the signalling pathways at work and the mechanisms by which alterations in the IIS pathway can extend lifespan.}, author = {Giannakou, Maria E. and Partridge, Linda }, citeulike-article-id = {2121340}, doi = {10.1016/j.tibs.2007.02.007}, journal = {Trends in Biochemical Sciences}, keywords = {aging, review}, month = {April}, number = {4}, pages = {180--188}, posted-at = {2007-12-14 22:56:16}, priority = {2}, title = {Role of insulin-like signalling in Drosophila lifespan}, url = {http://dx.doi.org/10.1016/j.tibs.2007.02.007}, volume = {32}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:2121340 L3 - citeulike-article-id:2121340 TI - Role of insulin-like signalling in Drosophila lifespan JF - Trends in Biochemical Sciences VL - 32 IS - 4 SP - 180 EP - 188 N2 - Regulation of lifespan by the insulin/insulin-like growth factor-like signalling (IIS) pathway has been conserved during evolution from the nematode worm to the mouse. In the insect Drosophila, regulation of lifespan by the IIS pathway was established by data showing that many mutations in single genes encoding IIS components result in an increase in lifespan. Recently, however, the focus has shifted from studying the effects of single gene mutations with ubiquitous effects to finding interventions that alter IIS in specific tissues and at specific stages in the life history of the fruitfly, in order to elucidate the signalling pathways at work and the mechanisms by which alterations in the IIS pathway can extend lifespan. KW - aging KW - review AU - Giannakou, Maria AU - Partridge, Linda PY - 2007/04// UR - http://dx.doi.org/10.1016/j.tibs.2007.02.007 ER -

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