Transcriptional regulation by insulin: from the receptor to the gene.

@article{citeulike:880673, abstract = {Insulin, after binding to its receptor, regulates many cellular processes and the expression of several genes. For a subset of genes, insulin exerts a negative effect on transcription; for others, the effect is positive. Insulin controls gene transcription by modifying the binding of transcription factors on insulin-response elements or by regulating their transcriptional activities. Different insulin-signaling cascades have been characterized as mediating the insulin effect on gene transcription. In this review, we analyze recent data on the molecular mechanisms, mostly in the liver, through which insulin exerts its effect. We first focus on the key transcription factors (viz. Foxo, sterol-response-element-binding protein family (SREBP), and Sp1) involved in the regulation of gene transcription by insulin. We then present current information on the way insulin downregulates and upregulates gene transcription, using as examples of downregulation phosphoenolpyruvate carboxykinase (PEPCK) and insulin-like growth factor binding protein 1 (IGFBP-1) genes and of upregulation the fatty acid synthase and malic enzyme genes. The last part of the paper focuses on the signaling cascades activated by insulin in the liver, leading to the modulation of gene transcription.}, address = {BioMed, Department of Biological Science, University of Quebec in Montreal, 141 President Kennedy, Montreal, QC H2X 3Y7, Canada.}, author = {Mounier, C. and Posner, B. I. }, citeulike-article-id = {880673}, doi = {http://dx.doi.org/10.1139/y05-152}, issn = {0008-4212}, journal = {Can J Physiol Pharmacol}, keywords = {insulin, review}, month = {July}, number = {7}, pages = {713--724}, posted-at = {2006-10-01 19:26:07}, priority = {3}, title = {Transcriptional regulation by insulin: from the receptor to the gene.}, url = {http://dx.doi.org/10.1139/y05-152}, volume = {84}, year = {2006} }

TY - JOUR ID - citeulike:880673 L3 - citeulike-article-id:880673 TI - Transcriptional regulation by insulin: from the receptor to the gene. JF - Can J Physiol Pharmacol VL - 84 IS - 7 SP - 713 EP - 724 AD - BioMed, Department of Biological Science, University of Quebec in Montreal, 141 President Kennedy, Montreal, QC H2X 3Y7, Canada. SN - 0008-4212 N2 - Insulin, after binding to its receptor, regulates many cellular processes and the expression of several genes. For a subset of genes, insulin exerts a negative effect on transcription; for others, the effect is positive. Insulin controls gene transcription by modifying the binding of transcription factors on insulin-response elements or by regulating their transcriptional activities. Different insulin-signaling cascades have been characterized as mediating the insulin effect on gene transcription. In this review, we analyze recent data on the molecular mechanisms, mostly in the liver, through which insulin exerts its effect. We first focus on the key transcription factors (viz. Foxo, sterol-response-element-binding protein family (SREBP), and Sp1) involved in the regulation of gene transcription by insulin. We then present current information on the way insulin downregulates and upregulates gene transcription, using as examples of downregulation phosphoenolpyruvate carboxykinase (PEPCK) and insulin-like growth factor binding protein 1 (IGFBP-1) genes and of upregulation the fatty acid synthase and malic enzyme genes. The last part of the paper focuses on the signaling cascades activated by insulin in the liver, leading to the modulation of gene transcription. KW - insulin KW - review AU - Mounier, C AU - Posner, BI PY - 2006/07// UR - http://dx.doi.org/10.1139/y05-152 ER -