Exogenous reinfection in tuberculosis

@article{citeulike:1466747, abstract = {Summary Whether the development of active tuberculosis in people with previous tuberculous infection represents an episode of endogenous reactivation or exogenous reinfection has been debated for decades. Articles proposing the unitary concept of pathogenesis of tuberculosis in the 1960s initiated a period in which reinfection was considered to be an uncommon cause of tuberculosis. To review evidence demonstrating the occurrence of tuberculosis due to exogenous reinfection, we did a literature search covering publications from 1966 until the present, and found that there was substantial evidence--both experimental and epidemiological--supporting the role of exogenous reinfection in tuberculosis. However, only models based on estimates of the annual risk of infection and the incidence of tuberculosis provided a quantitative estimate of the relative contribution of exogenous reinfection to the burden of tuberculosis. Better estimates of the contribution of exogenous reinfection to new cases of tuberculosis may need to be considered in tuberculosis control strategies.}, author = {Chiang, Chen-Yuan and Riley, Lee W. }, citeulike-article-id = {1466747}, comment = {Points to lots of interesting studies. Basically, exogenous reinfection is important, but no one has estimated it well. This is where I learned about using the zero of the Poisson distribution (number of uninfected people) to get the rate of inhalation of infectious doses.}, journal = {The Lancet Infectious Diseases}, keywords = {epidemiology, reinfection, tuberculosis}, month = {October}, number = {10}, pages = {629--636}, posted-at = {2007-07-19 08:54:08}, priority = {0}, title = {Exogenous reinfection in tuberculosis}, url = {http://www.sciencedirect.com/science/article/B6W8X-4H5MX31-P/2/af3779ae956bce785b4b8908993c7d0d}, volume = {5}, year = {2005} }

TY - JOUR ID - citeulike:1466747 L3 - citeulike-article-id:1466747 TI - Exogenous reinfection in tuberculosis JF - The Lancet Infectious Diseases VL - 5 IS - 10 SP - 629 EP - 636 N2 - Summary Whether the development of active tuberculosis in people with previous tuberculous infection represents an episode of endogenous reactivation or exogenous reinfection has been debated for decades. Articles proposing the unitary concept of pathogenesis of tuberculosis in the 1960s initiated a period in which reinfection was considered to be an uncommon cause of tuberculosis. To review evidence demonstrating the occurrence of tuberculosis due to exogenous reinfection, we did a literature search covering publications from 1966 until the present, and found that there was substantial evidence--both experimental and epidemiological--supporting the role of exogenous reinfection in tuberculosis. However, only models based on estimates of the annual risk of infection and the incidence of tuberculosis provided a quantitative estimate of the relative contribution of exogenous reinfection to the burden of tuberculosis. Better estimates of the contribution of exogenous reinfection to new cases of tuberculosis may need to be considered in tuberculosis control strategies. KW - epidemiology KW - reinfection KW - tuberculosis N1 - Points to lots of interesting studies. Basically, exogenous reinfection is important, but no one has estimated it well. This is where I learned about using the zero of the Poisson distribution (number of uninfected people) to get the rate of inhalation of infectious doses. AU - Chiang, Chen-Yuan AU - Riley, Lee PY - 2005/10// UR - http://www.sciencedirect.com/science/article/B6W8X-4H5MX31-P/2/af3779ae956bce785b4b8908993c7d0d ER -