Noisy translation of a single gene: fluctuations in protein synthesis from a single template

@misc{citeulike:2531984, abstract = {We introduce some new quantitative measures of fluctuations in the process of synthesis of proteins from a single messenger RNA (mRNA) template. We calculate the statistical distributions of these fluctuating quantities and extract the strength of the corresponding translational noise. For these calculations we use a model that captures both the mechano-chemistry of each individual ribosome as well as their steric interactions in ribosome traffic on the same mRNA track. By comparing our results for a specific gene of the {\it Escherichia coli} bacteria with those for the corresponding homogeneous mRNA template, we demonstrate the effects of the sequence inhomogeneities of real genes on the fluctuations and noise. We also suggest {\it in-vitro} laboratory experiments for testing our theoretical predictions.}, author = {Garai, Ashok and Chowdhury, Debashish and Ramakrishnan, T. V. }, citeulike-article-id = {2531984}, eprint = {0803.1558}, keywords = {biophysics, transcription}, month = {Mar}, posted-at = {2008-05-07 08:31:16}, priority = {2}, title = {Noisy translation of a single gene: fluctuations in protein synthesis from a single template}, url = {http://arxiv.org/abs/0803.1558}, year = {2008} }

TY - ELEC ID - citeulike:2531984 L3 - citeulike-article-id:2531984 TI - Noisy translation of a single gene: fluctuations in protein synthesis from a single template N2 - We introduce some new quantitative measures of fluctuations in the process of synthesis of proteins from a single messenger RNA (mRNA) template. We calculate the statistical distributions of these fluctuating quantities and extract the strength of the corresponding translational noise. For these calculations we use a model that captures both the mechano-chemistry of each individual ribosome as well as their steric interactions in ribosome traffic on the same mRNA track. By comparing our results for a specific gene of the {\it Escherichia coli} bacteria with those for the corresponding homogeneous mRNA template, we demonstrate the effects of the sequence inhomogeneities of real genes on the fluctuations and noise. We also suggest {\it in-vitro} laboratory experiments for testing our theoretical predictions. KW - biophysics KW - transcription AU - Garai, Ashok AU - Chowdhury, Debashish AU - Ramakrishnan, TV PY - 2008/Mar/11/ UR - http://arxiv.org/abs/0803.1558 ER -