Bounding the Size and Probability of Epidemics on Networks

@misc{citeulike:2764163, abstract = {We consider an infectious disease spreading along the edges of a network which may have significant clustering. The individuals in the population have heterogeneous infectiousness and/or susceptibility. We define the out-transmissibility of a node to be the marginal probability that it would infect a randomly chosen neighbor given its infectiousness and the distribution of susceptibility. For a given distribution of out-transmissibility, we find the conditions which give the upper [or lower] bounds on size and probability of an epidemic, under weak assumptions on the transmission properties, but very general assumptions on the network. We find similar bounds for a given distribution of in-transmissibility (the marginal probability of being infected by a neighbor). We also find conditions giving global upper bounds on size and probability. The distributions leading to these bounds are network-independent. In the special case of networks with high girth (locally tree-like), we are able to prove stronger results. In general the probability and size of epidemics are maximal when the population is homogeneous and minimal when the variance of in- or out-transmissibility is maximal.}, author = {Miller, Joel C. }, citeulike-article-id = {2764163}, eprint = {0803.0999}, keywords = {epidemiology}, month = {May}, posted-at = {2008-05-07 08:30:12}, priority = {3}, title = {Bounding the Size and Probability of Epidemics on Networks}, url = {http://arxiv.org/abs/0803.0999}, year = {2008} }

TY - ELEC ID - citeulike:2764163 L3 - citeulike-article-id:2764163 TI - Bounding the Size and Probability of Epidemics on Networks N2 - We consider an infectious disease spreading along the edges of a network which may have significant clustering. The individuals in the population have heterogeneous infectiousness and/or susceptibility. We define the out-transmissibility of a node to be the marginal probability that it would infect a randomly chosen neighbor given its infectiousness and the distribution of susceptibility. For a given distribution of out-transmissibility, we find the conditions which give the upper [or lower] bounds on size and probability of an epidemic, under weak assumptions on the transmission properties, but very general assumptions on the network. We find similar bounds for a given distribution of in-transmissibility (the marginal probability of being infected by a neighbor). We also find conditions giving global upper bounds on size and probability. The distributions leading to these bounds are network-independent. In the special case of networks with high girth (locally tree-like), we are able to prove stronger results. In general the probability and size of epidemics are maximal when the population is homogeneous and minimal when the variance of in- or out-transmissibility is maximal. KW - epidemiology AU - Miller, Joel PY - 2008/May/01/ UR - http://arxiv.org/abs/0803.0999 ER -