Selective inhibition of nucleic acid synthesis in Mycobacterium tuberculosis by isoniazid.

@article{gangadharam1963, author = {Gangadharam, P. R. and Harold, F. M. and Schaefer, W. B. }, citeulike-article-id = {956179}, comment = {Work in BCG. Kill curve does not show initial freeze, just immediate exponential death. Looks like inflection towards persister state at around 12h. Protein synthesis is not inhibited until between 12 and 24h, while DNA and RNA synthesis are inhibited within 6h. Maybe mRNA concentration isn't a limiting factor until late (if then)?}, issn = {0028-0836}, journal = {Nature}, keywords = {bcg, isoniazid, mtuberculosis, trp}, month = {May}, pages = {712--714}, posted-at = {2006-11-22 00:17:53}, priority = {0}, title = {Selective inhibition of nucleic acid synthesis in Mycobacterium tuberculosis by isoniazid.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/13946383}, volume = {198}, year = {1963} }

TY - JOUR ID - gangadharam1963 L3 - citeulike-article-id:956179 TI - Selective inhibition of nucleic acid synthesis in Mycobacterium tuberculosis by isoniazid. JF - Nature VL - 198 SP - 712 EP - 714 SN - 0028-0836 KW - bcg KW - isoniazid KW - mtuberculosis KW - trp N1 - Work in BCG. Kill curve does not show initial freeze, just immediate exponential death. Looks like inflection towards persister state at around 12h. Protein synthesis is not inhibited until between 12 and 24h, while DNA and RNA synthesis are inhibited within 6h. Maybe mRNA concentration isn't a limiting factor until late (if then)? AU - Gangadharam, PR AU - Harold, FM AU - Schaefer, WB PY - 1963/05/18/ UR - http://view.ncbi.nlm.nih.gov/pubmed/13946383 ER -