Epistasis correlates to genomic complexity

@article{citeulike:874298, abstract = {Whether systematic genetic interactions (epistasis) occur at the genomic scale remains a challenging topic in evolutionary biology. Epistasis should make a significant contribution to variation in complex traits and influence the evolution of genetic systems as sex, diploidy, dominance, or the contamination of genomes with deleterious mutations. We have collected data from widely different organisms and quantified epistasis in a common, per-generation scale. Simpler genomes, such as those of RNA viruses, display antagonistic epistasis (mutations have smaller effects together than expected); bacterial microorganisms do not apparently deviate from independent effects, whereas in multicellular eukaryotes, a transition toward synergistic epistasis occurs (mutations have larger effects together than expected). We propose that antagonistic epistasis might be a property of compact genomes with few nonpleiotropic biological functions, whereas in complex genomes, synergism might emerge from mutational robustness. 10.1073/pnas.0604543103}, author = {Sanju\'{a}n, Rafael and Elena, Santiago F. }, citeulike-article-id = {874298}, doi = {http://dx.doi.org/10.1073/pnas.0604543103}, journal = {PNAS}, keywords = {alife, epistasis, gene-networks, gene-regulation, grn}, month = {September}, number = {39}, pages = {14402--14405}, posted-at = {2008-07-25 10:16:02}, priority = {4}, title = {Epistasis correlates to genomic complexity}, url = {http://dx.doi.org/10.1073/pnas.0604543103}, volume = {103}, year = {2006} }

TY - JOUR ID - citeulike:874298 L3 - citeulike-article-id:874298 TI - Epistasis correlates to genomic complexity JF - PNAS VL - 103 IS - 39 SP - 14402 EP - 14405 N2 - Whether systematic genetic interactions (epistasis) occur at the genomic scale remains a challenging topic in evolutionary biology. Epistasis should make a significant contribution to variation in complex traits and influence the evolution of genetic systems as sex, diploidy, dominance, or the contamination of genomes with deleterious mutations. We have collected data from widely different organisms and quantified epistasis in a common, per-generation scale. Simpler genomes, such as those of RNA viruses, display antagonistic epistasis (mutations have smaller effects together than expected); bacterial microorganisms do not apparently deviate from independent effects, whereas in multicellular eukaryotes, a transition toward synergistic epistasis occurs (mutations have larger effects together than expected). We propose that antagonistic epistasis might be a property of compact genomes with few nonpleiotropic biological functions, whereas in complex genomes, synergism might emerge from mutational robustness. 10.1073/pnas.0604543103 KW - alife KW - epistasis KW - gene-networks KW - gene-regulation KW - grn AU - Sanjuán, Rafael AU - Elena, Santiago PY - 2006/09/26/ UR - http://dx.doi.org/10.1073/pnas.0604543103 ER -